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Increased hepatic mRNA expression of CAT was also reported in different diet-induced MASLD animal models (Jarukamjorn et al
In addition, L-theanine (100 mg/kg) could effectively regulate the metabolism of glucose, lipids, and proteins in SD rats, and the main mechanism was that L-theanine could upregulate the mRNA expression of phosphofructokinase (PFK), carnitine palmitoyltransferase 1 (CPT1), insulin receptor (IR), insulin receptor substrate (IRS), and liver kinase B1 (LKB1), and enhance the phosphorylation of adenosine 5-monophosphate-activated protein kinase (AMPK) (79)
46 High intratumoral expression of CYP3A4 can accelerate the metabolic inactivation of chemotherapeutic agents such as paclitaxel and docetaxel, thereby reducing local drug bioavailability, diminishing therapeutic efficacy, and ultimately contributing to drug resistance
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