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For example, LY3437943 , a novel triple agonist peptide discovered by Eli Lilly that targets the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and GLP-1R (GCGR+GIPR+GLP-1R from the list above), can effectively reduce body weight and improve glycemic control in obese mice
however, its clinical utility is limited by dose-dependent cardiotoxicity
Compare CAS 910463-68-2, molecular formula, molecular-weight reference, purity basis, fill size, net peptide content, HPLC purity, MS identity, salt or counter-ion notes when disclosed, storage guidance, lead time, MOQ, and whether the same document standard can be repeated across future batches
The conclusion was further validated by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and H&E staining (Fig
