TET1 orchestrates this process through both GPX4-dependent and -independent mechanisms

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This may exacerbate the course of MASLD by inhibiting lipolysis and increasing visceral fat deposition.The Trp64Arg polymorphism (rs4994) within the 3-adrenergic receptor (3-AR) gene has been implicated in an elevated susceptibility to MASLD in small-scale observational studies
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