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Although the clinical effect of l-asparaginase clearly indicates that asparagine is crucial for tumor survival and metastasis 52 , the importance of asparagine beyond protein synthesis and the mechanism by which asparagine supplementation enhances glutamine-associated metabolism are less well understood
FEBS Lett 140:310 Worthington MT, Cohn SM, Miller SK, Luo RQ, Berg CL (2001) Characterization of a human plasma membrane heme transporter in intestinal and hepatocyte cell lines
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(2) the half-life of the compound must be of sufficient duration to maintain a therapeutic level
Pairing IV sessions with dietary changes and reduced toxin exposure accelerates progress
