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20,287 Deleting SLC39A14 in TFR knockout mice significantly reduces hepatic iron accumulation, and inhibits ferroptosis-mediated liver fibrosis in high iron-diet mice
Free radicals are highly reactive molecules that damage cellular structures and contribute to the development of various diseases, including cancer, heart disease, and ageing
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First identified in 2012, it is defined by iron-dependent lipid peroxidation and the accumulation of lipid peroxides ( 2.1 Core machinery of ferroptosis The regulation of ferroptosis involves several key components, including GPX4, the cystine/glutamate antiporter system (System Xc-, composed of SLC7A11 and SLC3A2 subunits) and acyl-CoA synthetase long-chain family member 4 (ACSL4) ( Figure 1 )
Researchers should consult primary literature (PubMed, Google Scholar) before designing experiments and confirm dose-ranges, vehicle compatibility, and analytical methods against the published methodology
