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This dosing approach helps minimize the risk of adverse events, particularly severe gastrointestinal concerns, which are expected during the beginning of the therapy
Cohorts of 24 mice that had been previously housed together were analysed over a 24-h period (Bains et al, 2016)
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An enzyme called tyrosinase is needed to create melanin (the pigment that causes the brown spots) and while several other skin lightening agents work to inhibit the synthesis of tyrosinase itself (like vitamin C or licorice), arbutin lets tyrosinase be and rather hinders the melanin-forming activity of the enzyme
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