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Current FDA labeling for semaglutide products includes warnings or precautions involving: Acute pancreatitis Acute gallbladder disease Acute kidney injury due to volume depletion Severe gastrointestinal reactions Hypoglycemia when combined with insulin or insulin secretagogues Diabetic retinopathy complications in susceptible patients Serious hypersensitivity reactions Pulmonary aspiration risk during general anesthesia or deep sedation Semaglutide labeling also contains a boxed warning regarding thyroid C-cell tumors observed in rodents
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Most of the pathways in this part involve cytokines, starting from MAPK, TCR, or cAMP-PKA signaling, which results in an increase in anti-inflammatory cytokines and a decrease in pro-inflammatory cytokines
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Other possible symptoms may include headache or tiredness
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