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Clinical trial data suggests tirzepatide produces greater average weight loss than semaglutide, largely because it activates both the GLP-1 and GIP receptors rather than just GLP-1

In contrast, Retatrutide remains in the trial phase

Long-term glycaemic response and tolerability of dapagliflozin versus a sulphonylurea as add-on therapy to metformin in patients with type 2 diabetes: 4-year data

Some trials show up to an 80% reduction in liver fat, with nearly 90% of individuals returning to healthy liver fat levels