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In conclusion, macrophages activation and interchange are dynamic processes: the same KCs may take responsible for inflammatory promotion and hepatotoxicity first and then help down-regulate inflammation and repair injury [54, 61]

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The DHS-led survival advantage of mice was accompanied by an increase in the total GPx activity as well as mRNA expression levels of seleno-GPxs ( GPx1 , GPx2 , GPx3 , and GPx4 ), reduction of lipid peroxidation, and suppression of inflammatory response (decrease of the expressions of pro-inflammatory genes and infiltration of inflammatory cells) in the radiosensitive organs such as spleen, intestine, and lung