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doi: 10.1111/ijd.13585

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[10] [11] Similarly, the SURMOUNT-4 trial showed significant weight regain after tirzepatide discontinuation

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GLP-1RAs in the cardiovascular system In the cardiovascular system, GLP-1 can reduce cardiac ischemia-reperfusion injury through the activation of specific signaling pathways, such as the PI3K/Akt pathway

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That said, theres not yet enough long-term data to rule out ongoing risk

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