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Psoriatic arthritis from a mechanistic perspective
The activation of TFEB requires modification of a specific lysine residue in the translation initiation factor 5A (eIF-5A) generating what is called hypusine (derived from hy droxy pu trescine and ly sine ) which involves spermidine as outlined in the Polyamines in Protein Modification below
Second, manufacturing: injectable pens require sterile fill-finish capacity that simply can't scale quickly, and patients waited months in shortages
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