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This triggers the migration of occludin, which is another tight-junction complex, to the basolateral membrane

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Isolated proteases X(GD_Sh2)c and X(GD_Sh2)d retained activity on GD_Sh, but lost activity on GD_SS1.1, GD_SS1.2 and GD_SS2 (Extended Data Fig

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A genome-wide association study provides evidence of sex-specific involvement of Chr1p35.1 (ZSCAN20-TLR12P) and Chr8p23.1 (HMGB1P46) with diabetic neuropathic pain

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Yet, symptomatology is highly variable across individuals, shaped by underlying neurobiological factors

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Our findings validate a mechanism-targeted screening strategy, successfully identifying GA as an effective antagonist against the defined toxic pathway (ferroptosis/oxidative stress)

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