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This triggers the migration of occludin, which is another tight-junction complex, to the basolateral membrane
Isolated proteases X(GD_Sh2)c and X(GD_Sh2)d retained activity on GD_Sh, but lost activity on GD_SS1.1, GD_SS1.2 and GD_SS2 (Extended Data Fig
A genome-wide association study provides evidence of sex-specific involvement of Chr1p35.1 (ZSCAN20-TLR12P) and Chr8p23.1 (HMGB1P46) with diabetic neuropathic pain
Yet, symptomatology is highly variable across individuals, shaped by underlying neurobiological factors
Our findings validate a mechanism-targeted screening strategy, successfully identifying GA as an effective antagonist against the defined toxic pathway (ferroptosis/oxidative stress)
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