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The patient profile for non-GLP-1 peptides Metabolically healthy baseline: Fasting glucose, insulin, and lipids are within range, but stubborn fat remains
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Certain groups, such as pregnant or breastfeeding individuals, are advised to avoid this medication due to potential risks
Clinical trials show average weight loss of 1522% of body weight at 68 weeks
51 While high doses of semaglutide and tirzepatide have not been directly compared, the weight loss and incidence of gastrointestinal AEs for lower doses of semaglutide 1 mg and tirzepatide 5 mg were very similar when directly compared in the SURPASS-2 trial, implying that any potential impact of GIP on reducing nausea at lower doses is most likely marginal
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