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Friction in the right places is a feature, not a flaw

The glucagon receptor activation (paradoxically) adds metabolic benefits when paired with GLP-1 and GIP , such as promoting energy expenditure and fat oxidation, possibly combating the decrease in basal metabolic rate that accompanies weight loss, and helping reduce liver fat

Thus, both intrinsic and extrinsic factors play roles in urate production

Ive always suffered with confidence but losing one stone has made me feel so much better

Patients experiencing significant side effects despite these measures should discuss dose reduction or alternative treatment options with their diabetes team