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Semaglutide regulates lipid metabolism and polarization in tumor-associated macrophages (TAMs) through the PPARG/ACSL1 signaling pathway, transforming them from an M2 to an M1 polarized state to inhibit tumor progression

It may represent a threshold phenomenon that emerges only at higher exposure

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These include nausea, vomiting, diarrhea, constipation, bloating, and abdominal discomfort, especially during the early stages of treatment

This allows internalized NADs to dissociate from the fusogenic peptide delivery system and escape into the cytoplasm to exert their therapeutic effects