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SGLT2 inhibitors increase glucagon secretion according to some reports, and this might reduce the glucose-lowering effect [34]
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Kumar says that more research is needed to understand what drives these effects, and GLP-1s are not currently FDA-approved to treat addiction disorders
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However, they are being discussed within the medical community because they act on biological systems that are involved in many of the changes that occur during perimenopause and menopause
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GLP-1R is expressed on cocaine- and amphetamine-regulated transcript (CART)/proopiomelanocortin (POMC) neurons in the hypothalamus, which regulate satiety and termination of meals [40]
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