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Am J Psychiatry 159(4):663665 Scott F, Hampsey E, Gnanapragasam S et al (2022) Systematic review and meta-analysis of augmentation and combination treatments for early-stage treatment-resistant depression

INTRODUCTION Endometriosis afflicts 1 in 9 (11%) people assigned female at birth, 1 taking an average of 6.4 years from first symptoms to diagnosis

Anecdotal evidence suggests it may help with skin lightening, though scientific data remains limited

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Thus, the early environment can contribute substantially to the development of stable individual differences in HPA response to environmental stimuli, which may affect behavioral and neuroendocrine response to stressors