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We believe that the receptor uses the ER as a bridge to access other cellular organelles, opening exciting possibilities to find new ways to improve diabetes therapies." Professor Alejandra Tomas Catala Department of Metabolism, Digestion and Reproduction The paper, published in Nature Communications, uncovers how the GLP-1 receptor (GLP-1R) forms a specialised signalling hub inside pancreatic -cells that supports healthy mitochondria and boosts insulin secretion
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2022 [cited 4 August 2022] Drugs.com
Patients with prior GLP-1 intolerance, significant psychiatric comorbidity, or substantial renal/hepatic impairment benefit from individualized evaluation rather than high-volume screening
558 Furthermore, another Phase II trial (B-Sure) evaluated the durability of bepirovirsens antiviral effect (NCT04954859)
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