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The clinical trial protocol starts at 0.25 mg to 0.3 mg weekly and increases every 4 weeks through escalation steps of 0.6 mg, 1.2 mg, 1.8 mg, and finally 2.4 mg
Temperature excursions above 8C for more than 6 hours cause cumulative potency loss that no visual inspection can detect
The studied escalation started at 2mg weekly and increased by 2mg every 4 weeks to a 12mg maintenance dose
Symptoms can include fatigue, weakness, numbness or tingling in the hands and feet, difficulty walking, memory issues, and anemia
Tryptophan-Derived Neurotransmitters Tryptophan serves as the precursor for the synthesis of serotonin (5-hydroxytryptamine, 5-HT, see also Biochemistry of Nerve Transmission) and melatonin ( N -acetyl-5-methoxytryptamine)
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