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Understanding these patterns helps contextualize blood pressure observations within comprehensive cardiometabolic management

Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-naive patients with type 2 diabetes (SUSTAIN 4): a randomised, open-label, parallel-group, multicentre, multinational, phase 3a trial

Unlike earlier GHRPs (GHRP-2, GHRP-6), ipamorelin is highly selective for GHS-R1a without elevating ACTH, cortisol, prolactin, or aldosterone at therapeutic doses the most common reason it is preferred over non-selective GHRPs

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However, both can cause water retention, carpal tunnel symptoms, and effects on glucose metabolism at higher doses