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Multi-target combination: The combination of EGFR/VEGF dual-targeting inhibitors showed a synergistic effect in the KRAS mutation model (combination index CI = 0.32) (Yao et al., 2022)

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Two models of GBM cells and an intracranial xenograft mouse model were used to study GBM cells ferroptosis induced by transfection of small interfering RNAs (siRNAs) targeting C5aR1 and treatment with PMX205 [33], a pharmacological inhibitor of C5aR1