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A version of this story originally appeared in the Good News newsletter
For GLP-1 prescribing, that means verifying BMI eligibility (typically 30+ or 27+ with a weight-related comorbidity), screening for contraindications like personal or family history of medullary thyroid carcinoma or MEN2 syndrome, and titrating doses according to the drug's labeling
With a coming pipeline of weight loss drugs, this is a watershed moment
Despite these challenges, the eGFR slope has emerged as a clinically meaningful outcome, with evidence indicating a robust renoprotective effect from the combined use of GLP1-RA and SGLT2i
P.KelleyC.GrafR.et al (2009)
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