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The weekly check-ins and individualized dosing require active participation

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Although SUSTAIN 6 included patients with proliferative DR (PDR), who would be expected to require more interventions for retinopathy complications, some other CVOTs did not

And regulatory approvals already reflect this shift: Wegovy is approved to lower cardiovascular risk, Ozempic slows kidney disease progression, and semaglutide is cleared for metabolic dysfunctionassociated steatohepatitis (MASH) with fibrosis