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5-Amino-1MQ instead removes a drain on that route: by inhibiting NNMT it prevents nicotinamide from being methylated to 1-methylnicotinamide, leaving it available for NAMPT and the salvage pathway, and simultaneously spares the S-adenosyl-L-methionine that the methylation would have consumed
doi: 10.1002/micr.30990 5 BollettaATarantoGLoscoLEliaRSertGRibuffoDet al
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