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Several more frequently occurring forms of familial partial lipodystrophy (FPLD) exist in which affected individuals may have apparently modest changes in absolute adipose mass but redistribution or dysfunction of adipose tissues (1, 2)

The majority of preclinical studies examining how GLP-1RAs modify atherosclerosis have employed treatment regimens focused on attenuation of the development of atherosclerosis in genetically sensitized mice

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Women using oral contraceptives should discuss the potential for reduced effectiveness with their provider and consider using a backup or non-oral method for 4 weeks after tirzepatide initiation and after each dose increase

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