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The SURMOUNT clinical trial program, which established Zepbound's efficacy for weight management, included exploratory and secondary analyses of inflammatory biomarkers
Importantly, in active intestinal inflammation, HIF-2 may exert context-dependent effects on ferroptosis susceptibility: even under systemic iron deficiency, local inflammatory cues can paradoxically enhance epithelial iron uptake and/or perturb subcellular iron distribution, thereby increasing the labile iron pool and promoting lipid peroxidation
The termELR chemokine inhibitor refers to an agent which decreases the ability of CXCR1 and/or CXCR2 to bind to one or more (e.g., two, three, four, five, six, seven, or eight) of CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL7, and CXCL8
