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Tirzepatide patients lost an average of 20.2% of their body weight, while semaglutide patients lost 13.7%, a difference of 6.5 percentage points.[1] In practical terms, for someone starting at 250 pounds, that means losing roughly 50 pounds (22.8 kg) on tirzepatide versus 33 pounds (15.0 kg) on semaglutide.[1] Waist circumference shrank by an average of 7.2 inches (18.4 cm) with tirzepatide versus 5.1 inches (13.0 cm) with semaglutide, a difference with real implications for heart disease risk.[1] When researchers looked at more dramatic weight loss thresholds, tirzepatide pulled further ahead
While these medications are intended to manage type 2 diabetes, an off-label use is weight management
10.1038/s41467-024-52898-y 87 SandovalD
The findings suggest the drug that sheds the most weight is not the one with the strongest evidence of protecting the heart, and can also trigger the most lean mass loss and the most side effects
Doering, 2024b
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