Retatrutide targets GLP-1, GIP, and glucagon receptors simultaneously and has shown promising results in early-phase clinical trials
Additional but rare side effects include: low blood sugar (hypoglycemia) feeling cold unusual muscle pain dizziness slow or irregular heart rate trouble breathing metallic taste changes to nails on fingers and toes Low b12 levels DRUG INTERACTIONS As with other medications, metformin can interact with alcohol and certain medications, including angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, corticosteroids, hormone replacement therapy and estrogens, oral contraceptives, carbonic anhydrase inhibitors, nifedipine, thiazides or furosemide and other diuretics, phenothiazines, phenytoin, nicotinic acid (niacin), multidrug and toxin extrusion inhibitors, sympathomimetics, calcium channel blockers, isoniazid (antibiotic for tuberculosis), insulin and glyburide or other medications for diabetes, and medications for thyroid disease
Some users report flushing, similar to niacin, though this is less common with NR and NMN than with nicotinic acid
J Arthroplasty 39(3):716720
Tell your doctor if you have any problems with the injection or if you miss a dose