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Although NAION was rare and the event rate was low, an elevated risk was found in this study

doi: 10.1038/nature22394 41 MichelMCWielandTTsujimotoG

Both of the former are linked to the mitochondrial electron transport chain complex (ETC) to generate ATP, while the latter enters the Krebs cycle to generate citrate, which is then transferred to the cytoplasm for NADPH generation [63]