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SIRT1 targets both histone and non-histone substrates, including histones (e.g., H3K9, H4K16 31 ) and transcriptional regulators such as p53, 32 FOXO1/3a, 33 PGC-1, 34 LKB1, 35 and NF-B p65, 36 thereby contributing to epigenetic regulation and broader cellular functions
Lippincott Williams & Wilkins
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The body can produce L-Carnitine from the amino acids lysine and methionine, though it's also obtained through diet, especially from meat and dairy products
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