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Most patients notice reduced appetite and increased satiety within 2-3 weeks of starting injections, with measurable weight loss appearing by week 4-6
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The most significant published evidence to date comes from a phase 2 randomised controlled trial published in the New England Journal of Medicine in 2023, which evaluated retatrutide across multiple doses in adults with obesity
Split dosing does use the vial faster because you puncture the stopper more frequently, increasing contamination exposure slightly
Avoiding all of them for weeks can reduce diet quality without identifying the actual trigger
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