Iwai T, Suzuki M, Kobayashi K, Mori K, Mogi Y, Oka JI
Via the vagus nerve, gastrointestinal GLP-1 production stimulates the Arc and PVN in the hypothalamus as well as the NTS and area postrema, a locus of central nausea
Administered through a once-weekly injection, Dulaglutide ensures user-friendliness and supports greater compliance and contentment among patients due to its less frequent dosing schedule
These results show that although the expected therapeutic effect has not been achieved, AVV-based therapy has acceptable safety
The day of the assay, cells were washed in KRB-HEPES buffer (KRBH buffer: 135 mM NaCl, 3.6 mM KCl, 0.5 mM NaH 2 PO 4 , 0.5 mM MgSO 4 , 1.5 mM CaCl 2 , 2 mM NaHCO 3 , and 10 mM HEPES, pH 7.4) and 0.1% BSA, preincubated at 37 C for 30 min in KRBH-1% BSA and washed again in KRBH-0.1% BSA