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Importantly, the livers of patients with MASLD and mouse MASLD models display a distinct population of TREM2 + macrophages, and Trem2 deficiency in macrophages exacerbates mitochondrial dysfunction in hepatocytes by releasing exosomes containing high levels of miR-106b-5p, leading to MASLD progression [38]
doi: 10.1186/s13075-016-1218-4 92 ShiJLiJSuWZhaoSLiHLeiL
More than 100 Food and Drug Administration-approved drugs are peptide-based, including insulin and newer GLP-1 medications like Ozempic
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In animals with liver problems, where PC synthesis may be impaired, this has an additional therapeutically relevant effect
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