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A washout period of at least several weeks is advisable, though specific recommendations cannot be made given limited data
Besides, in ketogenic dietary interventions, FGF-21 reduces IL-1 secretion by macrophages, further alleviating systemic inflammation and metabolic dysfunction [256]
Research published in Nutrients (2023) and updated clinical reviews in early 2025 demonstrate that these SCFAs act as chemical keys that unlock the L-cells in your colon, directly triggering the release of GLP-1 into your bloodstream
In TRIUMPH-1 (general obesity population, 2,339 patients), the discontinuation rate was significantly lower at 11.3% now comparable to tirzepatide (6.2%)
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