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Therefore, multi-targeting or unimolecular peptides possessing combinatorial agonism at GIPR, GLP-1R and GCGR have been extensively explored and more than a dozen peptides including two GIPR/GLP-1R dual agonists, ten GLP-1R/GCGR dual agonists and five GIPR/GLP-1R/GCGR triagonists have entered into clinical development (Supplementary Fig
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Given the well-established role of the GLP-1 pathway in T2D management, CT-388 could potentially fit within the current standard of care in several ways: Weight Loss : CT-388 has demonstrated significant, rapid, and dose-proportional weight loss in the trial subjects, which is a key therapeutic goal in both obesity and T2D management
Segn datos del Observatorio de la Nutricin y de Estudio de la Obesidad, 2020, un 56 % de los adultos sufre obesidad (19 %) o sobrepeso (37 %)
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