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All participants in the orforglipron treatment arms started the study at a dose of orforglipron 1 mg once-daily and then increased the dose in a step-wise approach at four-week intervals to their final randomized maintenance dose of 3 mg (via a 1 mg step), 12 mg (via steps at 1 mg, 3 mg and 6 mg) or 36 mg (via steps at 1 mg, 3 mg, 6 mg, 12 mg and 24 mg)
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Combinations with physical therapy for musculoskeletal injuries, with standard medical therapy for gastrointestinal conditions, or with other regenerative peptides such as growth hormone secretagogues could provide synergistic benefits
When used appropriately, they can improve health markers and quality of life during this transitional phase
