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Across preclinical studies, Epitalon has shown: Telomerase activation and telomere extension: Via TRAP assays and fibroblast lifespan extension beyond the Hayflick limit Epigenetic remodeling: Reversal of chromatin aging, histone modulation, and gene promoter binding Redox homeostasis: Increased antioxidant enzymes (SOD, NQO1, catalase) and reduced ROS, lipid peroxidation, and DNA damage Circadian restoration: Upregulation of AANAT/pCREB, normalized melatonin and cortisol rhythms, and clock gene modulation in humans Cancer risk reduction: Reduced tumor multiplicity and delayed onset in HER-2/neu and colon cancer models
Weeks 34: 2 mg once weekly (Increase only if early GI symptoms are mild and stable) Weeks 58 : 4 mg once weekly Weeks 912: 8 mg once weekly Week 13+: 12 mg once weekly (Only escalate to higher doses if indicated and previous doses were well tolerated) Balanced schedule: Standard trial-inspired ramp This schedule follows a typical balanced titration pace similar to what many clinical trials use
November 2, 2023.
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