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For example, Wegovy gained additional approval in the UK to lower the risk of serious cardiovascular problems in the overweight and obese, and from FDA to reduce the risk of stroke and heart attack in the non-diabetic overweight and obese

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Adverse Effects Relevant to Drug Interactions Gastrointestinal Effects and Oral Drug Absorption Nausea and vomiting during dose escalation create secondary DDI risks

But the patient should know the combination has no trial data behind it, the additional cost is real, and the marginal benefit is unproven