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These mainly include: Pregnant or breastfeeding individuals, as angiogenesis and unknown systemic effects may harm fetal or infant development Anyone with a history of cancer: BPC-157 stimulates blood vessel growth, which could theoretically support tumor development Those taking prescription drugs or with chronic illnesses

And the zonula occludens proteins , ZO-1, ZO-2 and ZO-3, sit on the cytoplasmic face as scaffolds, linking the transmembrane components to the actin cytoskeleton which is how a junction can be actively pulled open rather than merely leaking