(b) Single small case series in knee pain A peer-reviewed article (Lee et al., Alternative Therapies in Health & Medicine , ~2021) describes: 12 patients with chronic knee pain Treated with intra-articular BPC-157, often combined with TB-500 7 of 12 reported symptom improvement lasting several months This study has major limitations: No control group No blinding No standardized outcomes (no KOOS, WOMAC, or imaging) Very small sample size Mixed interventions Conclusion: This study cannot demonstrate true benefit
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The peptide sequence only represents a small portion of the entire protein, and the full-length protein is usually a more complex structure with folds, alpha-helices, beta-sheets, and other structural motifs as well as various posttranslational modifications, any of which can shield the epitope from the antibody
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