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After the introduction of various tricyclics and selective serotonin re-uptake inhibitors (SSRIs), two competing ideas on the action of antidepressants became current, given the observed effectiveness of antidepressants only on chronic use: receptor desensitization and the modulation of second messenger systems (Feighner, 1999)

However, the recent shortages of FDA-approved semaglutide formulations have opened the door for compounded alternatives

To make it work, you need: High protein intake Structured resistance training A mild calorie deficit (not extreme) If calories drop too low, muscle gain becomes unlikely

Accessed July 18, 2025

But you do have to do some heavy sets relatively close to failure