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Daily administration increases the risk of methionine overload, elevated homocysteine, and gastrointestinal side effects without improving fat oxidation beyond what the liver can process
Each dose increase may trigger a brief 3- to 5-day nausea recurrence, but this pattern becomes less pronounced with successive increases
Agarwal A, Prabakaran SA
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The vehicle, excipients, injection volume, and delivery device can all influence local and systemic tolerability
