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Recent solution NMR structural studies have provided detailed molecular models of the p53 transactivation domain in complex with both the FOXO4 forkhead domain and FOXO4-DRI, advancing understanding of the precise molecular interactions that enable selective senescent cell targeting in research applications
Besides, selective anaplastic lymphoma kinase (ALK) inhibitors is a first-line therapy for nucleophosmin (NPM)-ALK-positive T cell lymphoma and echinoderm microtubule-associated protein like 4 (EML4)-ALK-positive non-small cell lung cancer (NSCLC) [133, 134]
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