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Awad MM, Oxnard GR, Jackman DM, Savukoski DO, Hall D, Shivdasani P, et al
The modifications made to human GLP-1 include: Amino acid substitutions that resist DPP-4 enzyme degradation Attachment of fatty acid chains (acylation) as seen in semaglutide and liraglutide Fusion with immunoglobulin fragments (as in dulaglutide) to increase molecular size These changes are designed using rational drug design principles and implemented through biotechnology
Our results are at odds with data published by Mody and collaborators who, in a larger population, found better performance in terms of adherence and persistence to therapy with dulaglutide as compared to OW semaglutide and OW exenatide in a larger population ( This study has strengths and limitations
Regulatory Crackdown on Surrogate Ads The Directorate General of Health Services (DGHS) issued a strict advisory this month against surrogate advertising
Led by researchers at NYU Langone Health, the new study showed that those who were prescribed GLP-1 agonists, mostly within three years of receiving their transplant, were 49 percent less likely to experience organ failurewhen the transplanted kidney stops functioning, and the patient has to resume dialysisthan those who had not been prescribed a GLP-1
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