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Human studies administering hexarelin multiple times daily or daily over several weeks have documented a progressive blunting of the GH response, consistent with GHSR-1a downregulation and desensitization
Some early research has explored potential effects of GLP-1 receptor agonists on neuronal function
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Immunoblot of indicated proteins in HeLa SLC25A39 knockout cells expressing indicated cDNAs (bottom)
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