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Sequence characteristics and domain organization of cysteinyl GSTs From the phylogenetic tree and the amino acid sequence alignments, there are key sequence differences that allow differentiation of each class

Highlights: Glutathione (GSH) targets multiple hallmarks of aging, such as oxidative stress and mitochondrial dysfunction, making it a prime candidate for longevity interventions

However, based on (i) its typical GST structure, (ii) the identification of another activity strictly requiring GSH, and (iii) the identification of additional more closely related Cys-GSTs (Yamada et al., 2005

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