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When levels fall low enough, oxidative stress accumulates, which is associated with fatigue, compromised immune response, accelerated skin aging, and increased strain on the liver
In the 1960s, Gell and Coombs defined allergy as an exaggerated or inappropriate immune response, and they divided allergic responses into four pathophysiological types: anaphylaxis (type I), antibody-mediated cytotoxic reactions (type II), immune complex-mediated reactions (type III), and cell-mediated delayed hypersensitivity (type IV) (2)
Molecular Cell Biology, 22 (2), 119
While there is no direct chemical interaction, both substances can lower the seizure threshold in susceptible individuals, and alcohol may worsen the side effects of the supplement, such as nausea or indigestion
Vitamin D, a neuro-immunomodulator: Implications for neurodegenerative and autoimmune diseases
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