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coli GCL also functions as a monomeric protein (Hibi et al., Biochemical studies of the GCL from plants revealed that these proteins are regulated by redox environment through a mechanism that differs from the heterodimeric enzymes (Jez et al., Arabidopsis GCL showed that the enzyme was inactivated by buthionine sulfoximine, a potent inhibitor of mammalian GCL, and used a random ter-reactant kinetic mechanism with a preferred order of binding for catalysis (Jez et al., 2+ , orients the glutamate -carboxylate for attack on the -phosphate of ATP, which is positioned by a second Mg 2+ and an active site lysine

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Oxidative stress is caused by an overproduction of oxidants or unbalanced defence mechanisms played by antioxidants and their related enzymes

Adenomatous polyps, Barretts esophagus, actinic keratoses, cervical dysplasia, and similar conditions represent tissue already partway down the path toward malignancy