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Bull Acad Natl Med

Senior investigator Hilda Gutierrez reports

While many safe and effective ingredients exist, some products may contain harmful substances like hydroquinone or mercury, which can lead to severe skin damage and health issues

For example, in a 2021 study, as little as 100mg of dihydroberberine increased berberine blood levels better than 500mg of HCl, and another 2021 study (by Indena, the company that makes Berbevis) found that a phytosomal preparation resulted in a tenfold improvement in bioavailability compared with HCl.48 51 Based on these studies, you might conclude that the two bioenhanced forms are superior to berberine HCl

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