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Chemoresistance towards EGFR inhibition by small molecule tyrosine kinase inhibitors such as gefitinib or erlotinib are common features in clinical trials
That restores the volume with fat-grafting, dermal fillers potentially, that resuspends, repositions, and removes any excess skin and replaces the soft tissue to its true position, and then also addressing the skin quality by reviving the skin whether that's through mechanisms such as radiofrequency, micro-needling or other things that improve the quality of the skin, Davidson said
Lancet (1987) 2(8571):13004
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